1 MCQs in Pediatrics for NEET PG
A 17-year-old boy presents with chronic productive cough, recurrent pneumonias, pancreatic insufficiency, and failure to thrive. Spirometry shows FEV1 45%, FVC 60%, FEV1/FVC 0.62. The flow-volume loop demonstrates the pattern marked **A** — scooped expiratory limb indicating airway obstruction — along with reduced overall lung volumes. Which of the following CFTR mutations is most commonly responsible for this mixed obstructive-restrictive pattern in advanced cystic fibrosis?
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