Neonatal Jaundice

A 3-day-old male neonate born to an O Rh-positive mother presents with jaundice. The infant is exclusively breastfed. On examination, the baby appears lethargic and has poor feeding. Serum bilirubin is 18 mg/dL (total), with direct bilirubin 0.8 mg/dL. Hemoglobin is 14.2 g/dL, reticulocyte count 2.1%, and blood smear shows no spherocytes. Direct antiglobulin test (DAT/Coombs) is negative. What is the most likely diagnosis?

A 3-day-old term neonate born to an O-positive mother presents with clinical jaundice. The mother is O-negative and unsensitized (indirect Coombs test negative at delivery). The infant's total serum bilirubin is 14 mg/dL. Which investigation is most appropriate to confirm hemolytic disease and guide management?

A 3-day-old term Indian neonate born via normal vaginal delivery presents with jaundice. Serum bilirubin is 16 mg/dL. The infant is breastfeeding well, passing stools normally, and has no signs of hemolysis. Weight loss is 7% from birth weight. What is the most appropriate next step in management?

Which of the following is the primary mechanism of unconjugated hyperbilirubinemia in physiological jaundice of the newborn?

A 2-day-old preterm neonate (32 weeks gestation) born to an Rh-negative, unsensitized mother presents with jaundice. Direct antiglobulin test (DAT/Coombs) is positive. Hemoglobin is 14 g/dL and reticulocyte count is elevated. What is the most common cause of hemolytic jaundice in this clinical scenario?