Neonatal Sepsis

A 5-day-old preterm neonate (32 weeks gestation) admitted to the NICU develops signs of sepsis. Blood and cerebrospinal fluid cultures are obtained. The neonate has been on broad-spectrum antibiotics for 3 days without clinical improvement. Which is the most common causative organism of late-onset neonatal sepsis (LONS) in this NICU setting?

A 3-day-old term neonate born to a mother with prolonged rupture of membranes (PROM >18 hours) presents with fever, poor feeding, and lethargy. Blood culture is pending. Regarding the empiric antibiotic regimen for neonatal sepsis in this age group, all of the following are correct EXCEPT:

A 5-day-old preterm neonate (32 weeks gestation) with respiratory distress syndrome is on mechanical ventilation and develops clinical signs of late-onset neonatal sepsis (LONS). Regarding the microbiology and risk factors of LONS, all of the following statements are true EXCEPT:

Which clinical feature best distinguishes early-onset neonatal sepsis (EONS) from late-onset neonatal sepsis (LONS) in a 2-week-old neonate presenting with fever and poor feeding?

What is the recommended empirical antibiotic regimen for suspected neonatal sepsis in the first 48 hours of life?