A newborn boy delivered at 38 weeks to a 42-year-old mother presents with bilateral cleft lip and palate, holoprosencephaly with alobar features, hypotelorism, microphthalmia, postaxial polydactyly of hands and feet, cutis aplasia of the scalp, and omphalocele. Echocardiography reveals a VSD and PDA. He has recurrent apneic spells requiring resuscitation. Karyotype analysis shows the abnormality marked **A** in the diagram. Which of the following is the most likely mechanism responsible for this chromosomal abnormality in this clinical context?
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