1 MCQs in Pediatrics for NEET PG
A 16-year-old girl from a family with Duchenne muscular dystrophy (DMD) presents with progressive proximal muscle weakness over 2 years, calf pseudohypertrophy, and an elevated serum CK of 3500 U/L. Genetic testing confirms she is a heterozygous carrier for a frameshift deletion in the DMD gene at Xp21. Echocardiography reveals dilated cardiomyopathy. The mechanism marked **A** in the pedigree — skewed X-inactivation (Lyonization) — explains her symptomatic presentation. Which of the following best describes the molecular basis for her clinical manifestations?
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