A 3-year-old boy presents with developmental delay, short stature, and a distinctive facial appearance with downslanting palpebral fissures, long eyelashes, and a beaked nose. His parents note broad, angulated thumbs and broad great toes. Chromosomal microarray confirms a microdeletion at the region marked **D** in the diagram. Which of the following best explains the pathophysiology of this condition?
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