1 MCQs in Pharmacology for NEET PG
A 61-year-old man with head and neck squamous cell carcinoma is undergoing cisplatin-based chemoradiation. After three cycles (cumulative dose 400 mg/m²), he reports bilateral high-pitched tinnitus and difficulty hearing consonants. Baseline audiometry was normal. The audiogram pattern marked **B** shows bilateral symmetric high-frequency SNHL starting at 6–8 kHz with sharp drop-off and preserved speech frequencies. Which of the following best explains the pathophysiological mechanism of this ototoxic pattern?
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