1 MCQs in Pharmacology for NEET PG
A 62-year-old man with chronic kidney disease (eGFR 28 mL/min/1.73 m²) and atrial fibrillation is prescribed warfarin for stroke prevention. His baseline INR is 1.2. After 5 days of warfarin 5 mg daily, his INR is 2.8 (target 2–3). On day 6, he develops acute diarrhea and is started on ciprofloxacin. By day 10, his INR is 4.2, and he presents with hematuria. Which of the following best explains the pharmacokinetic mechanism underlying this adverse interaction?
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