Para-clinicalPharmacology

Pharmacokinetics in hepatic disease; first-pass metabolism; bioavailability

1 MCQs in Pharmacology for NEET PG

1 Hard

Sample Questions

hard

A 52-year-old man with cirrhosis (Child-Pugh score 10) is prescribed a lipophilic drug that undergoes extensive first-pass hepatic metabolism. The drug has a normal oral bioavailability of 25% in healthy subjects. Which of the following pharmacokinetic changes would you MOST expect in this patient?

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