1 MCQs in Pharmacology for NEET PG
A 35-year-old man with normal renal and hepatic function is enrolled in a Phase II clinical trial for a novel antihypertensive agent. The drug exhibits first-order kinetics with an elimination half-life of 6 hours. A loading dose of 400 mg is administered, followed by maintenance doses of 100 mg every 8 hours. After 4 days of therapy, steady-state plasma concentrations are measured at 8 µg/mL. The drug has a volume of distribution (Vd) of 50 L and is 90% protein-bound. Which of the following statements regarding this drug's pharmacokinetics is INCORRECT?
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