Receptor Subtypes and Pharmacological Effects

A 58-year-old man with hypertension and benign prostatic hyperplasia (BPH) presents to the clinic. His current medications include lisinopril and finasteride. He complains of persistent urinary hesitancy and weak stream despite 6 months of finasteride therapy. On examination, his blood pressure is 148/92 mmHg. The urologist recommends adding an alpha-1 adrenergic antagonist. Which of the following agents would be the MOST selective for alpha-1A receptors in the prostate, thereby minimizing vasodilation and hypotension?

A 52-year-old man with hypertension presents with palpitations, tremor, and diaphoresis. Clinical examination reveals a blood pressure of 180/110 mmHg and heart rate of 110 bpm. A pheochromocytoma is suspected. Which investigation is most appropriate to confirm excessive catecholamine activity and localize the tumor?

A 52-year-old man with hypertension is started on a beta-blocker. Which of the following is the most common cardiovascular effect of non-selective beta-adrenergic receptor antagonism?

A 48-year-old woman with benign prostatic hyperplasia is prescribed an alpha-1 adrenergic antagonist. Which of the following is the most common tissue site where alpha-1 receptor blockade produces its therapeutic effect in this condition?

A 38-year-old woman with asthma and seasonal allergies is prescribed albuterol (salbutamol) inhaler for acute bronchospasm. She uses it 3–4 times daily for 2 weeks and reports tremor in her hands, palpitations, and mild anxiety. Her heart rate is 102 bpm at rest, and she has a fine tremor on finger extension. Spirometry shows FEV₁ of 78% predicted (baseline 85%). What is the most appropriate next step in management?