Blood Groups and Transfusion

A 28-year-old man (B Rh-positive) undergoes elective open-heart surgery and receives 6 units of B Rh-positive packed RBCs intraoperatively. On postoperative day 2, he develops jaundice, dark urine, and a hemoglobin drop from 10 g/dL to 6.5 g/dL. Reticulocyte count is 8.5%, total bilirubin 4.2 mg/dL (direct 1.8 mg/dL), and LDH 680 U/L. Direct antiglobulin test (DAT/Coombs) is strongly positive. Blood bank reports that the transfused blood was correctly typed and cross-matched. What is the most likely diagnosis?

Which of the following statements about the Rh blood group system is correct?

Regarding Rh blood group antigen and hemolytic disease of the newborn (HDN), all of the following are true EXCEPT:

A 32-year-old woman (O Rh-negative) presents to the emergency department with severe postpartum hemorrhage following vaginal delivery. She has received 4 units of O Rh-positive packed red cells transfused rapidly by the blood bank due to unavailability of O Rh-negative blood. Her hemoglobin is now 7.5 g/dL. On examination, she is tachycardic (HR 118/min) and hypotensive (BP 88/54 mmHg). What is the most appropriate next step regarding further transfusion management?

A 28-year-old man of Bombay blood group phenotype requires an emergency transfusion following a motor vehicle accident. His blood type is negative for A, B, and H antigens. Which investigation is most appropriate to confirm the diagnosis of Bombay blood group (hh phenotype)?