A 42-year-old woman with tuberous sclerosis complex presents with left flank pain and hematuria. Non-contrast CT abdomen shows a 6.5 cm well-circumscribed heterogeneous renal mass with areas of macroscopic fat (attenuation −80 to −110 HU) interspersed with soft tissue and tortuous vessels, as marked **C** in the diagram. Smaller similar lesions are noted bilaterally. Which of the following is the most important clinical implication of the macroscopic fat component seen in the structure marked **C**?
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