A 68-year-old male smoker is found to have a maximum infrarenal aortic diameter of 3.2 cm on screening ultrasound. The structure marked **A** in the diagram represents the fusiform infrarenal aortic dilatation. Which of the following pathophysiologic mechanisms is MOST directly responsible for the progressive enlargement of the structure marked **A** in abdominal aortic aneurysm?
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