A 52-year-old obese woman presents with 36 hours of severe right upper quadrant pain, fever (38.6°C), and positive Murphy's sign on examination. Ultrasound of the abdomen shows a distended gallbladder with an impacted stone at the neck, pericholecystic fluid, and positive sonographic Murphy's sign. The structure marked **A** in the diagram demonstrates a striated "double-rim" appearance with measurements exceeding 3 mm. According to the Tokyo Guidelines 2018, which of the following best describes the pathophysiologic significance of this finding in acute cholecystitis?
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