1 MCQs in Surgery for NEET PG
A 17-year-old woman with a family history of familial adenomatous polyposis (FAP) undergoes colonoscopy. The structure marked **A** in the diagram shows a dense carpet of hundreds to thousands of small adenomatous polyps throughout the colon with virtually no normal-appearing intervening mucosa. Genetic testing confirms a heterozygous APC truncating mutation at codon 1309. Which of the following best explains the molecular mechanism underlying the profuse polyposis phenotype seen in this patient?
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