1 MCQs in Surgery for NEET PG
A 16-year-old boy undergoes colonoscopy as part of familial screening. The endoscopy reveals the structure marked **A** in the diagram — a carpet of hundreds of adenomatous polyps studding the entire colonic mucosa. Genetic testing confirms a germline loss-of-function mutation in the APC gene on chromosome 5q22.2. Which of the following best explains the molecular mechanism underlying the development of this polyposis phenotype?
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