A 22-year-old hirsute male truck driver presents with a 2-year history of recurrent painful swellings in the natal cleft. He has a midline pit with protruding hair and a lateral secondary opening with induration. Contrast-enhanced CT shows the structure marked **A** (subcutaneous sinus tract from the midline pit tracking laterally to a fluid collection). Which of the following is the MOST IMPORTANT pathogenic mechanism in the formation of this structure marked **A**?
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