3 MCQs in Biochemistry for NEET PG
A 38-year-old woman from Delhi presents with a 3-month history of progressive fatigue, dyspnea on exertion, and recurrent oral ulcers. On examination, she has pallor, glossitis, and mild hepatosplenomegaly. Laboratory investigations reveal hemoglobin 7.2 g/dL, MCV 72 fL, serum B12 1200 pg/mL (normal), and serum folate 2.1 ng/mL (low). Bone marrow biopsy shows megaloblastic changes. A urine test reveals elevated orotic acid. Which enzyme deficiency best explains this clinical presentation?
Which enzyme catalyzes the first committed step of de novo pyrimidine synthesis?
Orotic aciduria Type I results from deficiency of which enzyme complex?
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