1 MCQs in Medicine for NEET PG
A 38-year-old never-smoker presents with exertional dyspnea and chronic cough. Spirometry shows FEV1 52% predicted with FEV1/FVC 0.55, TLC 128%, and severely reduced DLCO (38%). Serum alpha-1 antitrypsin is 28 mg/dL (normal 150–350 mg/dL) and genotyping confirms PiZZ phenotype. HRCT demonstrates basal-predominant panacinar emphysema with lower-lobe bullae. Which of the following management approaches, marked **C** in the diagram, represents the disease-modifying intervention most strongly supported by evidence in alpha-1 antitrypsin deficiency?
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