1 MCQs in Medicine for NEET PG
A 58-year-old man presents with newly diagnosed acute myeloid leukemia (AML) with a white blood cell count of 85,000/μL and 72% blasts on bone marrow examination. Cytogenetics shows a normal karyotype. Molecular testing reveals an internal tandem duplication (ITD) mutation in the gene located at the locus marked **A** (13q12.2). The allelic ratio of this mutation is 0.6. Which of the following best describes the pathogenic mechanism and prognostic significance of this mutation?
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