A 42-year-old previously healthy man presents with fever, fatigue, and dyspnea on exertion. Examination reveals pallor, oral candidiasis, and cervical lymphadenopathy. CBC shows WBC 68,000/μL with 46% myeloblasts and monocytes, hemoglobin 8.1 g/dL, and platelets 34,000/μL. Bone marrow biopsy demonstrates myelomonocytic blasts with abnormal eosinophils exhibiting basophilic granules. Cytogenetic analysis reveals the karyotype shown. The chromosomal abnormality marked **B** in the diagram—a pericentric inversion of chromosome 16 producing the CBFB-MYH11 fusion—defines which of the following AML entities and carries what prognostic significance?
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