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    SubjectsMedicineBronchiolitis Obliterans Post-HSCT
    ClinicalMedicine

    Bronchiolitis Obliterans Post-HSCT

    1 MCQs in Medicine for NEET PG

    1 Medium
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    Sample Questions

    medium

    A 45-year-old man underwent allogeneic HSCT for acute myeloid leukemia 18 months ago. He now presents with progressive dyspnea on exertion and dry cough. Pulmonary function testing shows FEV1/FVC ratio of 0.68, FEV1 at 68% predicted (decline of 12% from pretransplant baseline), and RV/TLC ratio of 125%. Expiratory HRCT demonstrates mosaic attenuation with air trapping in small airways. Microbiologic workup including BAL is negative for infection. The condition marked **B** in the diagram is suspected. Which of the following best describes the pathophysiologic mechanism underlying this pulmonary complication?

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