A 35-year-old Southeast Asian man is resuscitated from ventricular fibrillation that occurred during sleep. His 12-lead ECG shows coved-type ST-segment elevation ≥2 mm in leads V1–V2 with descending negative T-waves and incomplete right bundle branch block morphology. Echocardiography and cardiac MRI are normal. His father died suddenly during sleep at age 38, and his paternal uncle died suddenly at age 42. His older brother has Type 2 Brugada pattern that converted to Type 1 after ajmaline challenge. The inheritance pattern shown in the pedigree is marked as **A** in the diagram. Which of the following best describes the genetic and molecular basis of this inheritance pattern?
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