A 45-year-old male presents with episodic epigastric burning pain for 6 months occurring 2–3 hours after meals and at night (hunger pain), classically relieved by food or antacids. He is a chronic smoker (20 pack-years) and H. pylori-positive. He denies NSAID use. Upper GI endoscopy reveals the lesion marked **A** in the diagram—a 1 cm crater with whitish fibrinous base and surrounding erythematous edematous mucosa in the duodenal bulb. Rapid urease test from antral biopsy is strongly positive, and stool H. pylori antigen is confirmatory. Which of the following is the MOST APPROPRIATE INITIAL MANAGEMENT STRATEGY?
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