A 38-year-old man presents with a 3-year history of asthma diagnosed at age 35, now complicated by recurrent sinusitis with nasal polyps, a 2-week history of wrist drop, and a petechial rash on the lower extremities. Laboratory work shows peripheral eosinophilia of 2200/μL and p-ANCA positivity. Spirometry reveals an obstructive pattern with FEV1/FVC ratio of 0.68 and 15% improvement in FEV1 post-salbutamol, as marked **A** in the diagram. Which of the following best explains the pathophysiology of the airway obstruction pattern shown at **A**?
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