1 MCQs in Medicine for NEET PG
A 58-year-old man presents with progressive headaches and focal neurological deficits over 3 months. MRI brain shows a heterogeneous mass in the left frontal lobe with central necrosis, thick irregular peripheral enhancement, and crossing of the corpus callosum producing a butterfly configuration (marked **A** in the diagram). The surrounding T2/FLAIR hyperintense signal extends well beyond the enhancing margin. Histopathology confirms WHO Grade 4 astrocytoma with IDH-wildtype status. Which of the following molecular alterations is MOST characteristic of this tumor and carries prognostic significance for treatment response?
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