A 42-year-old woman presents with a 6-month history of fatigue, weight gain, and cold intolerance. On examination, she has a diffusely enlarged, firm, rubbery thyroid gland. Thyroid ultrasound shows a markedly heterogeneous gland with diffuse hypoechogenicity and micronodulation creating a "Swiss cheese" pattern. The structure marked **B** in the diagram is most consistent with this presentation. Which of the following autoimmune mechanisms is MOST characteristic of the pathogenesis of this condition?
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