A 45-year-old man of Northern European descent presents with fatigue, arthralgia in the second and third metacarpophalangeal joints, and hepatomegaly. Serum transferrin saturation is 68% and ferritin is 1200 ng/mL. HFE genotyping reveals the genotype marked **B** in the diagram. Which of the following best describes the expected phenotype and clinical course in this patient?
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