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    SubjectsMedicineHereditary Hemochromatosis HFE C282Y
    ClinicalMedicine

    Hereditary Hemochromatosis HFE C282Y

    1 MCQs in Medicine for NEET PG

    1 Medium
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    Sample Questions

    medium

    A 45-year-old man from North India presents with progressive fatigue, joint pain in the 2nd and 3rd metacarpophalangeal joints, and hepatomegaly. Serum ferritin is 850 ng/mL and transferrin saturation is 62% (fasting). HFE genotyping confirms homozygosity for the C282Y mutation. His parents are both clinically well but have not been genotyped. The inheritance pattern shown in the pedigree at **A** — with two affected siblings born to unaffected parents — is most consistent with which mode of inheritance?

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