A 24-year-old man presents with infertility after two years of unprotected intercourse. On examination, he is tall with eunuchoid body habitus, bilateral gynecomastia, and small firm testes (<6 mL). Semen analysis shows azoospermia. Serum testosterone is low at 180 ng/dL (normal 300–1000), and FSH/LH are markedly elevated. His karyotype is shown in the diagram marked **B**. Which of the following best describes the pathophysiological basis of his testicular failure in this condition?
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