Malaria — Clinical

A 28-year-old man from West Bengal presents with 5 days of high fever (40.5°C), severe headache, confusion, and focal seizures. Blood smear confirms P. falciparum with 8% parasitemia. He is hypotensive (BP 90/60 mmHg) and has a Glasgow Coma Scale of 12. What is the drug of choice for immediate treatment?

A 32-year-old man from rural Bihar presents with fever, chills, and sweating for 5 days. Blood smear examination reveals ring forms and trophozoites. Which is the most common cause of malaria in India?

A 28-year-old woman from Assam with malaria develops severe headache, altered mental status, and seizures. Which is the most common organ system affected in severe malaria?

A 32-year-old man from rural Odisha presents to the emergency department with a 5-day history of fever, chills, and headache. He reports that fever spikes occur every 48 hours, accompanied by rigors and profuse sweating. On examination, he is febrile (39.5°C), with mild splenomegaly and jaundice. His hemoglobin is 9.2 g/dL, platelet count is 65,000/μL, and serum bilirubin is 3.8 mg/dL (predominantly indirect). Peripheral blood smear shows ring forms and Schüffner's stippling. What is the most likely diagnosis?

A 28-year-old woman from Mumbai presents with a 7-day history of high-grade fever, severe headache, and altered mental status. On examination, she is febrile (40.2°C), confused, with neck stiffness and positive Kernig's sign. Her blood pressure is 92/58 mmHg, respiratory rate 28/min, and oxygen saturation 88% on room air. Laboratory investigations show hemoglobin 7.8 g/dL, WBC 12,500/μL, platelets 35,000/μL, serum creatinine 2.8 mg/dL, and serum bilirubin 6.2 mg/dL. Peripheral blood smear reveals >5% parasitemia with multiple ring forms and absent mature forms. What is the most appropriate immediate management?