A 38-year-old Indian woman presents with symptomatic hypercalcemia (serum calcium 11.8 mg/dL, PTH 145 pg/mL) and is found to have parathyroid hyperplasia on imaging. Genetic testing reveals a germline loss-of-function mutation in the gene located at the locus marked **B** in the diagram. Which of the following best describes the molecular mechanism by which this mutation predisposes to tumor development in MEN1 syndrome?
Ready to test yourself?
Test your Medicine knowledge with AI-powered MCQs and detailed explanations — no signup required to try.
Sign up free and practice all 1 MEN1 (Menin) MCQs with AI-powered explanations tailored to your performance.
Create Free Account