A 28-year-old woman with a 15-year history of focal impaired-awareness seizures presents with recurrent episodes of epigastric rising aura, déjà vu, and oral automatisms followed by post-ictal confusion. She has failed trials of levetiracetam, lamotrigine, and lacosamide. High-resolution 3T MRI with epilepsy protocol shows the finding marked **A** in the diagram. Which of the following statements best characterizes the pathological substrate underlying her seizure disorder?
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