A 68-year-old man presents with progressive fatigue, bone pain in the back and ribs, and recurrent infections. Laboratory studies reveal hemoglobin 8.4 g/dL, serum calcium 12.6 mg/dL, creatinine 2.8 mg/dL, and serum protein electrophoresis showing an M-spike of 4.8 g/dL. Skull radiographs demonstrate the pattern marked **C** in the diagram—multiple well-defined punched-out lytic lesions with sharply demarcated margins and no sclerotic rims, creating a "pepper-pot" appearance. Bone marrow biopsy shows 58% clonal plasma cells. Which of the following best explains the pathophysiology of the bone lesions marked **C**?
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