A 12-year-old boy presents to the pediatric outpatient department with multiple café-au-lait macules (>5 mm), axillary freckling, and cutaneous neurofibromas. Slit-lamp examination reveals bilateral Lisch nodules. MRI brain shows an optic pathway glioma. The karyotype marked **B** in the diagram shows a deletion at 17q11.2. Which of the following best explains the molecular consequence of this chromosomal deletion in neurofibromatosis type 1?
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