A 68-year-old man of Anglo-Saxon descent presents with progressive deep aching bone pain, cranial enlargement requiring larger hat sizes, bilateral hearing loss, and anterior bowing of the left tibia. Radiographs show marked calvarian thickening with a characteristic cotton-wool appearance, basilar invagination, and flame-shaped lytic advancing edges in long bones. Serum alkaline phosphatase is markedly elevated at 1250 U/L. The structure marked **D** in the diagram represents the radiographic findings of this condition. Which of the following is the PRIMARY PATHOPHYSIOLOGIC MECHANISM underlying the radiographic appearance marked **D**?
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