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    SubjectsMedicinePedigree — Polygenic / Multifactorial Inheritance: Type 2 Diabetes Mellitus
    ClinicalMedicine

    Pedigree — Polygenic / Multifactorial Inheritance: Type 2 Diabetes Mellitus

    1 MCQs in Medicine for NEET PG

    1 Hard
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    Sample Questions

    hard

    A 52-year-old man of Indian origin presents with type 2 diabetes mellitus diagnosed 2 years ago. His mother, maternal uncle, and eldest son all have type 2 diabetes. His BMI is 28 kg/m², and he has central obesity. Genetic testing for single-locus mutations (MODY, neonatal diabetes genes) is negative. The pedigree pattern shown in the diagram at **A** represents the inheritance pattern most consistent with his family history. Which of the following BEST characterizes the genetic architecture and inheritance mechanism illustrated at **A**?

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