1 MCQs in Medicine for NEET PG
A 45-year-old man presents with fatigue, early satiety, left upper quadrant discomfort, and drenching night sweats over three months. Examination reveals massive splenomegaly. Complete blood count shows WBC 210,000/μL with left shift including myelocytes, metamyelocytes, and promyelocytes; basophilia 7%; hemoglobin 10.4 g/dL; platelets 620,000/μL. Leukocyte alkaline phosphatase is low. Bone marrow shows myeloid hyperplasia with M:E ratio 15:1. Karyotype analysis reveals the abnormality marked **D** in the diagram. Which of the following best explains the molecular basis of this cytogenetic finding and its role in disease pathogenesis?
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