1 MCQs in Medicine for NEET PG
A 32-year-old male current smoker (20 pack-year history) presents with progressive dyspnea, dry cough, and a second spontaneous left pneumothorax. HRCT chest shows bizarre-shaped thin-walled cysts and centrilobular nodules in the upper and middle lobes with sparing of costophrenic angles. Lung biopsy confirms Langerhans cell histiocytosis with CD1a+ and Langerin+ cells. His pulmonary function tests show: FVC 78% predicted, FEV1 60% predicted, FEV1/FVC ratio 65%, TLC 95% predicted, RV 110% predicted, and DLCO 45% predicted. The pattern marked **B** in the diagram best represents his spirometric and diffusion findings. Which of the following mechanisms BEST explains the disproportionately reduced DLCO in this patient's PFT pattern?
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