1 MCQs in Medicine for NEET PG
A 52-year-old Indian man presents with progressive fatigue, joint pain in the 2nd and 3rd MCP joints, and recent-onset diabetes mellitus. Laboratory investigations reveal elevated transferrin saturation (58%) and serum ferritin of 850 ng/mL. HFE genotyping confirms C282Y homozygosity. His 48-year-old sister, who is also C282Y homozygous, remains asymptomatic with normal ferritin levels. The inheritance pattern demonstrated by hereditary hemochromatosis in this family exemplifies the pattern marked **A** in the diagram. Which of the following BEST explains why the brother is clinically symptomatic while the sister remains asymptomatic despite identical HFE genotypes?
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