A 28-year-old Indian male presents with premature graying of hair, bilateral cataracts, scleroderma-like skin changes, and recurrent ankle ulcers. He has short stature and normal pubertal development was delayed. Genetic testing reveals biallelic loss-of-function mutations in the gene located at the locus marked **B** in the diagram. Which of the following best explains the cellular basis for his accelerated-aging phenotype?
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