COVID-19 / SARS-CoV-2

A 58-year-old man with type 2 diabetes mellitus presents with a 5-day history of fever, cough, and dyspnea. RT-PCR for SARS-CoV-2 is positive. Chest X-ray shows bilateral ground-glass opacities. SpO₂ is 88% on room air. He has no contraindications to antivirals. What is the drug of choice for treatment of this moderate COVID-19?

A 42-year-old woman with no comorbidities presents with a 3-day history of fever, sore throat, and mild cough. RT-PCR confirms SARS-CoV-2 infection. She is fully vaccinated. SpO₂ is 96% on room air, and she has no respiratory distress. She is at high risk for severe disease due to recent chemotherapy for breast cancer. What is the drug of choice for early treatment?

During the second wave of COVID-19 in India, a 38-year-old woman is admitted with severe pneumonia. Laboratory investigations reveal elevated D-dimer, prolonged PT/INR, and thrombocytopenia. Which of the following is the most common thrombotic complication in severe COVID-19?

A 52-year-old man from Delhi presents with fever, cough, and dyspnea on day 8 of illness. Chest X-ray shows bilateral ground-glass opacities. Which finding would best distinguish moderate COVID-19 pneumonia from severe COVID-19 pneumonia requiring ICU admission?

Which of the following is the primary protease enzyme in SARS-CoV-2 that is targeted by nirmatrelvir (a component of Paxlovid)?