Hepatitis A, B, C, D, E — Virology

A 42-year-old man with a 10-year history of hepatitis B (HBeAg-positive, HBV DNA 6 × 10^5 IU/mL) and compensated cirrhosis (Child-Pugh A) presents for routine follow-up. He has no prior treatment. Ultrasound shows no features of hepatocellular carcinoma. What is the most appropriate next step in management?

A 45-year-old man with a 15-year history of intravenous drug use presents with fatigue, jaundice, and abdominal pain. He reports multiple episodes of acute hepatitis in the past. On examination: hepatomegaly, ascites, and spider angiomas. Laboratory findings: ALT 180 IU/L, AST 320 IU/L (AST > ALT), bilirubin 6.5 mg/dL, albumin 2.8 g/dL, PT prolonged (INR 2.1). Serology: HBsAg positive, anti-HBc IgG positive, anti-HBe positive, HBeAg negative, anti-HDV positive, anti-HCV positive. What is the most likely diagnosis?

All of the following statements about hepatitis viruses are correct EXCEPT:

A 28-year-old woman with genotype 1b chronic hepatitis C (HCV RNA 2.5 × 10^6 IU/mL) and no cirrhosis presents for treatment. Which of the following is the preferred first-line regimen?

A 32-year-old man from rural India presents with acute hepatitis. Serological testing shows anti-HAV IgM positivity. Which of the following is the most common mode of transmission for this infection?