1 MCQs in Microbiology for NEET PG
A 6-year-old girl from rural Maharashtra presents with recurrent oral candidiasis, hypocalcemia (corrected calcium 6.8 mg/dL), and hyponatremia. Investigations show elevated parathyroid hormone and elevated ACTH with low cortisol. Genetic testing reveals a homozygous mutation in the AIRE gene. The process marked **D** in the thymic maturation diagram (negative selection) is impaired in this patient. Which of the following best explains the pathophysiology of her autoimmune manifestations?
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