Diabetic Retinopathy

A 52-year-old man with type 2 diabetes mellitus presents with diabetic macular edema (DME) confirmed on optical coherence tomography (OCT). Central subfield thickness is 380 µm. He has no prior treatment for DME. What is the drug of choice for intravitreal injection in this patient?

A 52-year-old man with type 2 diabetes mellitus (HbA1c 9.2%) presents with blurred vision for 3 weeks. On examination, visual acuity is 6/9 in both eyes. Dilated fundoscopy reveals multiple dot and blot hemorrhages, hard exudates in a circinate pattern around the macula, and microaneurysms in the temporal periphery. No vitreous hemorrhage or neovascularization is noted. What is the most appropriate next step in management?

A 52-year-old man with type 2 diabetes for 8 years presents with blurred vision. Fundoscopy reveals dot-blot hemorrhages, hard exudates, and microaneurysms. Which single feature best distinguishes nonproliferative diabetic retinopathy (NPDR) from proliferative diabetic retinopathy (PDR)?

A 48-year-old woman with poorly controlled type 2 diabetes (HbA1c 10.2%) undergoes routine dilated fundoscopy. She is found to have multiple microaneurysms, dot-blot hemorrhages, and hard exudates in the four quadrants, but no cotton-wool spots, intraretinal microvascular abnormalities, or neovascularization. She is asymptomatic with visual acuity 6/6 in both eyes. Which investigation is most appropriate to determine if she requires immediate laser photocoagulation?

Which of the following is the earliest clinically detectable sign of diabetic retinopathy?