A 35-year-old man presents with acute leukemia. Bone marrow examination reveals ≥20% blasts with both myeloid and monocytic differentiation, and notably, abnormal eosinophils with large basophilic granules and unsegmented nuclei. Cytogenetics shows the translocation marked **A** in the diagram. Which of the following best explains the pathogenic mechanism of this translocation and its clinical consequence?
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