1 MCQs in Pathology for NEET PG
A 55-year-old man with newly diagnosed chronic lymphocytic leukemia presents with bulky bilateral cervical, axillary, and abdominal lymphadenopathy, constitutional symptoms, and an absolute lymphocyte count of 52.8 × 10⁹/L. Flow cytometry confirms CD5+, CD19+, CD20-dim, CD23+ kappa-restricted B cells. Interphase FISH analysis reveals the cytogenetic abnormality marked as **A** in the diagram—a deletion encompassing the ATM tumor suppressor gene locus. Which of the following best characterizes the prognostic and therapeutic significance of this finding?
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