1 MCQs in Pathology for NEET PG
A 68-year-old man presents with asymptomatic lymphocytosis (WBC 42 × 10⁹/L, 84% lymphocytes) discovered on routine screening. Peripheral blood smear shows small mature lymphocytes with clumped chromatin and Gumprecht cells. Flow cytometry confirms CD5+, CD19+, CD23+ B-cell population with dim surface immunoglobulin. Interphase FISH analysis reveals the cytogenetic abnormality marked **A** in the diagram (three signals for D12Z3 alpha-satellite probe in 78% of nuclei). Which of the following best describes the prognostic significance of this finding in the Dohner CLL risk hierarchy?
Ready to test yourself?
Test your Pathology knowledge with AI-powered MCQs and detailed explanations — no signup required to try.
Sign up free and practice all 1 Chronic Lymphocytic Leukemia with Trisomy 12 MCQs with AI-powered explanations tailored to your performance.
Create Free Account