Coagulation Disorders

A 32-year-old woman with a lifelong history of easy bruising and recurrent epistaxis is found to have a prolonged bleeding time and normal PT/aPTT. Platelet count is 150,000/µL. Which of the following is NOT a feature of von Willebrand disease?

A 28-year-old man with a history of recurrent thrombosis (deep vein thrombosis at age 24, pulmonary embolism at age 27) presents for hypercoagulability workup. Which of the following is NOT associated with inherited thrombophilia?

A 35-year-old woman with a lifelong history of easy bruising and menorrhagia is found to have a prolonged aPTT, normal PT, and normal platelet count. Mixing study corrects the aPTT. Which finding best distinguishes Factor V deficiency from Factor VIII deficiency?

A 28-year-old man with no prior bleeding history presents with acute onset of severe thrombocytopenia (platelets 8,000/μL), microangiopathic hemolytic anemia (schistocytes on blood smear), acute kidney injury, fever, and neurological symptoms. Which investigation is most specific for confirming the diagnosis of thrombotic thrombocytopenic purpura (TTP)?

A 35-year-old woman presents with a 2-year history of recurrent spontaneous bruising, epistaxis, and menorrhagia. Platelet count is 45,000/μL. Bone marrow examination shows adequate megakaryocytes. Which investigation is most appropriate to confirm the suspected diagnosis of immune thrombocytopenia?